منابع مشابه
Polymyxin B dosing in obese and underweight adults.
TO THE EDITOR—Sandri et al [1] recently reported important population pharmacokinetic data on intravenous polymyxin B in critically ill patients. They conclusively demonstrate that the dosage of polymyxin B should not be based on kidney function. Although no specific dosage regimen is recommended, the inference from this work is that polymyxin B should be dosed on total body weight (TBW). Unfor...
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1. Horton WA, Hecht JT. Disorders for which defects are poorly understood or unknown. In: Nelson Textbook of Pediatrics, 20th edn. Eds. Kliegman RM, Stanton BF, St. Gema JW, Schor NF, Behrman RE. Philadelphia: WB Saunders Co, 2011. p.3379. 2. Krishnamurthy S, Srinivasan S. Severe thrombocytosis as initial manifestation of Caffey disease in a 4 month old infant. Pediatr Blood Cancer. 2012;59:345...
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The data base for rational guidelines to safe, efficacious drug prescribing in adults with renal insufficiency are presented in tabular form. Current medical literature was extensively surveyed to provide as much specific information as possible. When information is lacking, however, recommendations are based on pharmacokinetic variables in normal subjects. Nephrotoxicity, important adverse eff...
متن کاملAntimicrobial dosing in obese patients.
Although the dose of some drugs is commonly adjusted for weight, weight-related dosage adjustments are rarely made for most antimicrobials. We reviewed the English-language literature on antimicrobial pharmacokinetics and dosing in obesity. Although there are many potential pharmacokinetic consequences of obesity, the actual effect on the pharmacokinetics and clinical efficacy of most antimicro...
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Background. Current guidelines for systemic vancomycin dosing recommended using actual body weight (ABW) regardless of body mass index (BMI). We sought to evaluate the effect of this dosing strategy in obese patients with BMI ≥35. Methods. Retrospective cohort study of patients ≥18 years old with a BMI ≥35 hospitalized between January 1, 2011 and December 31, 2013 with at least 3 doses of intra...
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ژورنال
عنوان ژورنال: Australian Prescriber
سال: 2017
ISSN: 1839-3942
DOI: 10.18773/austprescr.2017.053